Select all that apply:
The interstitial substance of bone matrix:
A. includes an organic portion that makes upapproximately one third of the matrix.
B. contains an organic protein portion that isproduced and secreted by osteoblasts.
C. contains an inorganic portion of calciumphosphate crystals, known as hydroxyapatite.
D. requires the deposition of the organicmatrix, the osteoid before the inorganic salts can bedeposited.
E. may incorporate cations that are chemicallysimilar to calcium, including heavy metal ions.
