Essay Question: Describe the allosteric regulation of phosphfructokinase during glycolysis. Please be very descriptive.

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Biology

Essay Question: Describe the allosteric regulation ofphosphfructokinase during glycolysis. Please be verydescriptive.

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The enzyme Phosphofructokinase1PFK1 catalyzes the transferof the phosphoryl group from ATP to fructose6Phosphate and yeildFructose16bis phosphate This reaction is irreversible undernormal cellular conditions and is the first committed step inglycolysis The reaction goes as follows The reaction occurs in presense of Mg2 ionNow Glucose6Phosphate which is an isomer ofFructosephosphate can flow either into glycolysis or some otherpathways such as pentose phosphate pathway or glycogenesis PFK1catalyzes the reaction that commits the glucose into glycolyticpathway PFK is a complex tetrameric enzyme in case of mammals itis composed of three different subunits M LP in differentcombinations in different tissue types For example in musclesPFK1 is composed of four M subunits becoming a homotetramerwhereas in erythrocytes it may See Answer

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