What are the growth conditions and mechanisms that regulate the production and activity of glutamine synthetase.

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Medical Sciences

What are the growth conditions and mechanisms that regulate theproduction and activity of glutamine synthetase.

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The scale of a single cell organ or organism glutaminehomeostasis is to a large extent determined by the activities ofglutaminase GA and glutamine synthetase GS the two enzymesthat are the focus of this report GA and GS each provide examplesof regulation of gene expression at many different levels In thecase of GA two different genes hepatic and kidneytype GAencode isoforms of this enzyme The expression of hepatic GA mRNAis increased during starvation diabetes and high protein dietthrough a mechanism involving increased gene transcription Incontrast the expression of kidney GA mRNA is increasedposttranscriptionally by a mechanism that increases mRNA stabilityduring acidosis We See Answer

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