The side chain of Asp 94 on the bchain of hemoglobin is in close proximity to the imidazole ring ofHis 146 on the b chain in the deoxy form of hemoglobin but not theoxy form.
1. What kind of interaction occursbetween Asp 94 and His 146 in the deoxy form of hemoglobin?
2. Is the imidazole ring of Hisprotonated or unprotonated? Explain.
3. The proximity of Asp 94 alters thepK value of the imidazole ring of His. In what way?
