The following data are simulated for a 200 mg dose of a drug given p.o. and...

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Biology

The following data are simulated for a 200 mg dose of a druggiven p.o. and i.v. VD = 500L Rate of absorption (oral only) =0.0096 min-1 (IV bolus was assumed 100% absorption immediately)Rate of elimination = ke = 0.0099 min-1 Therefore, eliminationhalf-life (t1/2) = 0.693/ke = 70 min Calculate the AUC of both p.o.and i.v. doses. I suggest using the trapezoidal method forcalculating AUC: sum of [{avg of two points}*{time between twopoints}]. Then calculate the bioavailable fraction (F).
Time (min)
Cp (ug/L)
1
3.78
5
17.8
10
33.2
15
46.2
30
74.4
45
89.9
60
96.7
90
94.9
120
83.4
180
55.4
240
33.5
360
11.0
420
6.14
540
1.90
Time (min)
Cp (ug/L)
1
396
5
381
10
362
15
345
30
297
45
256
60
221
90
164
120
122
180
67.3
240
37.2
360
11.3
420
6.26
540
1.91

Answer & Explanation Solved by verified expert

3.7 Ratings (632 Votes)

For OPSTEP 1 Plot Average concentration Cp versus timeSTEP 2 Calculate Area under the curve using the formulaAUCn cn cn12 x TimeintervalFor POTime minPO CpAvg See Answer

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Time (min)	Cp (ug/L)
1	3.78
5	17.8
10	33.2
15	46.2
30	74.4
45	89.9
60	96.7
90	94.9
120	83.4
180	55.4
240	33.5
360	11.0
420	6.14
540	1.90

Time (min)	Cp (ug/L)
1	396
5	381
10	362
15	345
30	297
45	256
60	221
90	164
120	122
180	67.3
240	37.2
360	11.3
420	6.26
540	1.91