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Summarise the timecourse of the IL-6 response to an acute bout of prolonged strenuous exercise, and...

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Medical Sciences

Summarise the timecourse of the IL-6 response to anacute bout of prolonged strenuous exercise, and evaluate the majorsource of IL-6 secreted in response to exercise and the purpose ofits secretion. (200 words)

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Interleukin 6 IL6 is an interleukin that acts as both a proinflammatory cytokine and an antiinflammatory myokine In humans it is encoded by the IL6 gene Function IL6 is an important mediator of fever and of the acute phase response It is capable of crossing the bloodbrain barrier and initiating synthesis of PGE2 in the hypothalamus thereby changing the bodys temperature setpoint It is now recognized that contracting skeletal muscle may synthesize    See Answer
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