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pMice that are completely lacking the Adenine nucleotide translocase gene (Ant-/-) are viable (which is surprising)...

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Chemistry

pMice that are completely lacking the Adenine nucleotidetranslocase gene (Ant-/-) are viable (which is surprising) and showthe following physiological phenotypes:

nHighlevels of alanine, lactate and succinate (inserum).

nAsix-fold increase of mitochondrial hydrogenperoxide as compared with normal control mice.

pGive reasonable biochemicalexplanations to each ofthese observations.

Answer & Explanation Solved by verified expert
3.6 Ratings (602 Votes)
Adenine nucleotide translocase ANT is an enzyme that catalyses the exchange of ADP ATP across the mitochondrial membrane This constitutes about 10 of mitochondrial proteinUnder respiring conditions ATP generated by oxidative phosphorylation is exported    See Answer
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