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It is a well-known phenomenon observed in drug addiction, that larger and larger doses of drugs...

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Medical Sciences

It is a well-known phenomenon observed in drug addiction, thatlarger and larger doses of drugs are required over time to get thesame effect (or high). Explain why this occurs based on theregulation of receptors the drug binds to and what feedbackmechanism is involved.

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Drug tolerance is a pharmacological concept which describes subjects reduced reaction to a drug following its repeated use Increasing its dosage may reamplify the drugs effect however this may accelerate tolerance further    See Answer
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