How important (quantitatively) is variation in genes affecting the Tor pathway to human longevity? Please support answer with...

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How important(quantitatively) is variation in genes affectingthe Tor pathway to human longevity?
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mTOR research started in 1970s with yeast and Rapamycin identified from Streptomyces bacteria Till now very few population studies have been completed SNPs may play vital role in mTOR pathway and its other regulating and interdependent genes For latest literature update you may read review by Kennedy BK etal wwwcellcomcellmetabolismpdfS15504131281629302273pdf One more latest review from M Kaeberlein httpjournalssagepubcomdoi1011770300985815591082 Harries LW etal studied the expression of mTORrelated transcripts in two populations InCHIANTI population study of aging and the San Antonio Family Heart Study SAFHS Expression of 2756 InCHIANTI and 1944 SAFHS genes were associated with age after correction for multiple testing 8 genes were robustly associated with age in both cohorts Genes involved in insulin signaling PTEN PI3K PDK1 ribosomal See Answer

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