DP Logan has just discovered the protein adamantiumase which has the hydrophobic signal sequences shown...

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DP Logan has just discovered the protein adamantiumase which has the hydrophobic signal sequences shown in the top image Below that I ve drawn four possible arrangements of this protein in the ER membrane The C and N termini are labelled for each protein as are the cytosolic and ER lumen sides of the membrane Which protein orientation is correct N term Cytosol ER membrane ER lumen option 1 option 3 option 2 option 1 N N q option 2 C term AM N option 3 option 4 N

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