Describe in detail as great a detail as possible the mechanism by which skeletal muscle cells...

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Medical Sciences

Describe in detail as great a detail as possible the mechanismby which skeletal muscle cells contract. Start with
an action potential arriving at an axon terminal of a motorneuron and end with the completion of a single cross-
bridge cycle. Be sure you describe all the events and how theoperate, and name all the structures, ions, proteins,
molecules involved and explain the role each has. Use properterminology and explain what is happening at
each step. Then explain what has to occur in order for a musclecell to relax. This will require a full page.

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Action potential arriving at axon terminal of a motor neuron cause the release of neurotransmitter AcetylcholineAchinto the Synapse of neuromuscular JunctionThis acetyl choline binds to the nicotinic acetyl choilne receptor in the muscle fibreThe nicotinic acetylcholine receptor a ligandgated cation channel admits both K and NaThe acetylcholine causes opening of a cation channel in the receptor capable of transmitting 1500030000 Na or K ions a millisecond Since the resting potential of the muscle plasma membrane is near EK the potassium equilibrium potential opening of acetylcholine receptor channels causes little increase in the efflux of K ions Na ions on the other hand flow into the muscle cell The simultaneous increase in permeability to Na and K ions produces a net depolarization to about 15 mV from the muscle resting potential of 85 to 90 mV This See Answer

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