CFTR is present in many other types of epithelial cells,including in the lung and in the pancreas. Cholera does nottypically affect these tissues, since infection occurs in the gut,and cholera toxin does not move into the bloodstream. However, somepeople have a mutation in CFTR that decreases its activity, andthus reduces the release of chloride ions from the cytosol ofepithelial cells into the lumen of these organs. Which of thefollowing are the most likely consequences of such CFTR mutations?(select two answers)
no change in fluid secretion from the tissues where CFTR isexpressed
decreased fluid secretion from the tissues where CFTR isexpressed
increased fluid secretion from the tissues where CFTR isexpressed
no change in susceptibility to cholera infection
decreased susceptibility to cholera infection
increased susceptibility to cholera infection
