Case study 8-year old girl with recurrent infections caused by Streptococcus pyogenes and Hemophilus influenza was admitted...

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Case study
8-year old girl with recurrent infections caused byStreptococcus pyogenes and Hemophilus influenza was admitted to thehospital following a 5-day sinus infection. Her mother noted thatshe had developed a productive cough and high fever. Her whiteblood cell count was 3200/ul (normal count 5000-9000/ul). 25%percent of her white cells were neutrophils (very low), 40% werelymphocytes (normal), and 29% were monocytes (elevated, normal 2 to8%). A serum test revealed that her IgG level was 35 mg/dl (normal600-1500 mg/dl), IgA was undetectable (normal 150-225 mg/dl) andher IgM level was 210 mg/dl (normal 75-150 mg/dl). A flowcytometric analysis of her peripheral blood cells revealed that allof her B cells were IgM⁺, IgD⁺.
1. Explain the fact the all patientâ€™s B cells were IgM+,IgD+.

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patients with influenza were somewhat more likely to have fever 68 vs 40 cough 93 vs 80 and nasal congestion 91 vs 81 than patients with other infectionsIn 90 of all patients with probable influenza lymphopenia andor monocytosis were present Relative lymphopenia with or without monocytosis appears to be a laboratory marker for H1N1 virus infection a finding See Answer

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