Background about the p53 i. What is p53? ii. What are its functions iii. How does post-translational modifications...

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Biology

Background about the p53
i. What is p53?
ii. What are its functions
iii. How does post-translational modifications of protein such asphosphorylation, acetylation and ubiquitination affect p53functions
iv. What is the role of MDM2 protein in regulating the biochemicalstability of p53 protein
v. What is the composition/domains within p53 protein
vi. What are genes regulated by p53
vii. What it is essential to activate p53 in cancer
viii. What are most common mutations prevalent in p53 gene
ix. How does these mutations impact p53 protein and functions
x. Describe the structure and the role of DNA binding domain ofp53
xi. Is there a relation between various cancers and type ofmutations

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3.9 Ratings (413 Votes)

1P53 is a protein it is also called as the guardian of the cell cycle it is the tumor suppressor gene presant on the 17th chromosome it is presant in all tissues it is having short life span in normal cell 2It regulates cell cycle with interacting with different proteins it repairs DNA it activates apoptosis pathway 3 See Answer

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