3. A 23-year-old woman presents to her GP with menorrhagia. The GP requests a coagulation screen...

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Medical Sciences

3. A 23-year-old woman presents to her GP withmenorrhagia. The GP requests a coagulation screen and the resultsof this are shown below:
The prolonged PT and APTT correct in a 50:50 mix withnormal plasma.
Test
Patient
Reference Range
PT
34s
11-14s
APTT
82s
23-35s
Fibrinogen (Clauss)
2.6g/L
1.5-4.0g/L
Thrombin Time
13s
10-13s
1. What questions might you ask this lady that would beof relevance?
2. How would you proceed with the investigation of thispatient?
A 45-year-old man presents with an extensive above kneeDVT extending into the iliac veins. He is otherwise well with nopast medical history of note.

His pre-anticoagulation screen shows:
Test
Patient
Reference Range
PT
14s
11-14s
APTT
>120s
23-35s
Fibrinogen (Clauss)
3.2g/L
1.5-4.0g/L
Thrombin Time
13s
10-13s
1. What is the most likely diagnosis?
Factor XII:C <1 IU/dl.
Do you think the FXII deficiency is clinicallyimportant?
If you elect to treat this patient with unfractionatedheparin how would you monitor this?

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QuestionA 23yearold woman presents to her GPwith menorrhagia The GP requests a coagulation screen and theresults of this are shown belowThe prolonged PT and APTT correct in a 5050 mix with normalplasmaTestPatientReference RangePT34s1114sAPTT82s2335sFibrinogen Clauss26gL1540gLThrombin See Answer

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Test	Patient	Reference Range
PT	34s	11-14s
APTT	82s	23-35s
Fibrinogen (Clauss)	2.6g/L	1.5-4.0g/L
Thrombin Time	13s	10-13s