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1)Please explain the role of alloimmune antibodies in graft rejection? 2)What is the cause of the tissue...

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Biology

1)Please explain the role of alloimmune antibodies in graftrejection?

2)What is the cause of the tissue injury in DTH reactions?

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4.2 Ratings (658 Votes)
1 Role of alloimmune antibodies in graft rejection Pathophysiology of chronic rejection strongly supports that inflammation and subsequent tissue remodeling during the posttransplant period cause exposure of cryptic selfantigens SAgs or their determinants within the graft which along with a subsequent cytokine response leads to loss of peripheral tolerance These events lead to the activation of cellmediated immunity towards development of de novo immune responses to SAgs There is also evidence for a role for interplay between allo and    See Answer
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