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1. Glucokinase and hexokinase perform the same enzymatic function yet their role in carbohydrate metabolism /...

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Chemistry

1. Glucokinase and hexokinase perform the same enzymatic functionyet their role in carbohydrate metabolism / homeostasis issubstantially different. a. Describe their cellular distribution /locations, functions, enzyme kenetics, and their regulation ofeach. b. Describe how each contributes to glucose homeostasis. c.Describe how insulin and glucagon may regulate these two enzymes.2. The liver is centrally involved in the regulation of bloodglucose levels. a. Describe what and how the liver contributes toglucose levels in both fed and fasted states b. Describe themolecular sources of substrates for glucose production. It isimportant to discuss the cellular source of these molecules as wellas the physiological conditions in which they would be produced. c.Explain how and why blood glucose concentrations becomedis-regulated during both fed and fasted states with type IIdiabetes.

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4.0 Ratings (407 Votes)
Hexokinase is very crucial enzyme in carbohydrate metabolism it phosphorylates 6carbon sugar so that they can enter in to metabolic pathways Glucokinase is most important isoform of hexokinase because it specifically act only glucose sugar it phosphorylates glucose to produce Glucose 6phosphate Hexokinase has four important isozymes and they differ in subcellular locations kinetics with respect to different substrates and conditions and physiological function They are denoted as hexokinases I II III and IV or hexokinases A B C and D Hexokinase I II and III have low Km value ie very high affinity for glucose molecules Hexokinase I is located in all mammalian tissues and is also called as housekeeping enzyme It get less affected by physiological hormonal and metabolic changes Hexokinase II is the main regulated isoform in many cell types Its activity found to be increased in cancerous cells This hexokinase is located in muscle and heart Hexokinase II is also located in the mitochondria Hexokinase III We have very little information about its    See Answer
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