1. Cells become cancerous after mutations accumulate in thevarious genes that control

		a. aerobic respiration
		b. immunological surveillance by NK cells
		c. mitochondrial biogenesis
		d. the ability of virus to enter cells
		e. the cell cycle

2.

let's say CFTR (encoding the CFTR Cl- channel) has two alleles:+ (which encodes a functional product) and - (which encodes anon-functional product). CFTR is a Cl- transporter expressed inmany epithelial cells. LDLR is on chromosome 7. A person with the-/- genotype has Cystic Fibrosis but those with either +/- or +/+genotypes do not. Which of the following is true?

		a. Cystic Fibrosis is autosomal recessive because a person musthave two copies of the \"-\" allele to express the phenotype
		b. Cystic Fibrosis is autosomal dominant because the \"+\" alleleis the normal version
		c. Cystic Fibrosis is autosomal dominant because the \"+\" alleleis the most common in the population
		d. Cystic Fibrosis is autosomal dominant, because a person musthave two copies of the \"-\" allele to express the phenotype
		e. Cystic Fibrosis is autosomal recessive because it is the \"-\"allele that causes the disease

3.

let's say SLC2A4 (encoding the insulin-dependent glucosetransporter GLUT4) has two alleles: + (which encodes a functionalproduct) and - (which encodes a non-functional product). If GLUT4expression is necessary to not have diabetes,which of the following can we definitely conclude? (More than oneanswer may seem correct but only one answer logically follows theinformation)

		a. a +/- genotype will have a mild form of diabetes
		b. a -/- genotype will have diabetes
		c. a -/- genotype may not have diabetes
		d. a +/- genotype will have a 50% probability of diabetes
		e. a +/+ genotype will not have diabetees

4.

a pretty good definition of a gene is

		a. one of the homologous chromosome inherited from either theegg (mother) or sperm (father)
		b. a discrete segment of DNA that encodes a functionalproduct
		c. one of two or more alternative forms of nucleotide that ariseby mutation and are found at the same place on a chromosome.
		d. the mRNA that is translated into a polypeptide
		e. the bluprint for the phenotype

5.

In the chart:

A	B	C	D
+/+	100% functional protein	watery	no disease
+/-	50% functional protein	intermediate	no disease
-/-	0% functional protein	thick	disease

What is in column A?

		a. different genes
		b. different phenotypes
		c. different genotypes
		d. different loci
		e. different proteins