Your book has a wonderful term for the coordinated control of glycolysis and gluconeogenesis: reciprocal. One is...

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Chemistry

Your book has a wonderful term for the coordinated controlof glycolysis and gluconeogenesis: reciprocal.
One is stimulated when the other is suppressed. But notonly physiological conditions have such effect -- so do individualcompounds found in cells.
A key control point in the pathways are the stepscatalyzed by phosphofructokinase (in glycolysis) andfructose-1,6-bisphosphatase (in gluconeogenesis). Let's zero in onthis spot.
A. Identify 3 compounds that act reciprocally on these twoenzymes (inhibiting one and activating the other).
B. Now, explain why the buildup of each of these, in turn,makes sense physiologically. Why, for instance, does it make sensethat AMP activates phosphofructokinase and but inhibitsfructose-1,6-bisphosphatase? Answer that and then answer a similarquestion for the other two effector molecules that you identifiedin part A.

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3.9 Ratings (623 Votes)

1 AMP stimulates phosphofructokinase whereasATP and citrate inhibit it Fructose16bisphosphatase on the other hand isinhibited by AMP and activated bycitrate2 A high level of AMP See Answer

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