You are expected to prepare a human pedigree detailing theinheritance of a single
genetic disease or disorder.
The pedigree will be created from the following information:
â— There are five generations.
â— In generation 1, there are two families.
o family one, the male is affected; this family should be listed onthe
left.
o family 2 the female is affected.
â— In generation 2 there are 12 individuals. Information on thisgeneration:
o family 1 had 7 children, family 2 had four.
o family 1 first three children were girls, the remainderboys
o family 2 had a girl, two boys, and another girl.
o the eldest female of family 1 was married.
â–ª She went on to have one daughter, and then one male,
affected
o the youngest male of family 1 and the eldest female of family2
were married. This youngest male was affected.
â–ª They went on to have five children. One girl, two boys, and
two more girls. The eldest boy, and two youngest girls were
all affected.
â–ª The eldest daughter went on to have a boy and a girl.
o the youngest daughter of family 1, and both males of family 2,were
affected.
â— In generation 3 there are at least 9 members.
o The youngest girl of the merged family had two sons. The firstdied
at birth and it is unknown if he was affected. The second was
affected
o The second oldest daughter of the merged family had oneaffected
male. She was not married.
o A daughter was born, who was a descendant of family 1 only,
whose mother was unaffected
â–ª Her father was affected.
â–ª She also has an adopted brother
â–ª She went on to have twin daughters
â–ª She was not married
â— In generation 4 there are 7 members.
o Four of five males were affected
â— In generation 5 there are 2 members.
â— Generation one is dead.
â— Non-married partners are not included in the pedigree.
â— Unless specified assume all individuals have marriedparents.
â— Unless specified, assume all spouses are unaffected
You will provide all genotypes for the second generation and ensureall known affected
individuals are marked.
After depicting the disease on the pedigree, you should includedetermine its dominant
or recessive inheritance pattern, and its autosomal or sex-linkedposition in the human
genome. Then, you will research a condition that matches thispattern and describe it in
full. Also, you should include a brief description of themanifestations and clinical
outcomes of the disease. The written portion of the assignmentshould be completed in
Microsoft Word.
