You are an MD/PhD student studying left-right laterality defects in humans. You are monitoring a pregnancy...

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Biology

You are an MD/PhD student studying left-right lateralitydefects in humans. You are monitoring a pregnancy in which theheart and stomach are positioned on the incorrect side of the body,while the rest of the organs are positioned normally.
a) [2pts] What would be the name of this type ofvisceral organ defect?
You are able to perform corrected surgery on the infantsoon after birth. You perform a genetic analysis and discover thischild had a mutation in a stretch activated calciumchannel.
b) [2pts] What are the normal roles of stretch activatedcalcium channels?
c) [4pts] Why might this mutation cause the left-rightlaterality defects you observed?
d) [4pts] Assuming that mouse and humanleft-right patterning are achieved through similar mechanisms whatwould you predict Nodal expression in the LPM would have lookedlike in this human patient during early development? Explain yourthinking.

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4.1 Ratings (593 Votes)

1 This visceral organ defect is known as Situs inversus in which major visceral organs are position is reverse direction to their normal position or simply are mirrored from their normal positions It is an autosomal recessive genetic condition 2 The normal function of See Answer

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