You are a prominent cancer scientist leading a government laboratory, you just received bottle of colon...
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Biology
You are a prominent cancer scientist leading a governmentlaboratory, you just received bottle of colon cancer biopsy alongwith some normal colon tissue collected from a patient.
(A) Describe and give examples of the traditional ways andmodern omics methods you would use in classifying this colon tumortissue.
(B) After a week, additional clinical testing results of thepatient came back, the colonoscopy failed to find any polyps, andyour latest lab test result also indicated the MLH1 gene expressionwas lost in the tumor sample.
1.Ă‚Â Ă‚Â Based on these data, which genetic disease would yousuggest the patient is suffering from? (1 mark)
2.Ă‚Â Ă‚Â Name and describe the cellular process by which ofMLH1 is involved; and outcome of losing MLH1 gene expression .
3.  Name and describe the molecular basis of the processby which often involved in driving diminished expression of MLH1 . Describe also molecular mechanism a normal cell would useto counter act the “process” .
(C) Describe in details the advanced laboratory techniques bywhich you could use to study the “process” occurred to the MLH1locus.
You are a prominent cancer scientist leading a governmentlaboratory, you just received bottle of colon cancer biopsy alongwith some normal colon tissue collected from a patient.
(A) Describe and give examples of the traditional ways andmodern omics methods you would use in classifying this colon tumortissue.
(B) After a week, additional clinical testing results of thepatient came back, the colonoscopy failed to find any polyps, andyour latest lab test result also indicated the MLH1 gene expressionwas lost in the tumor sample.
1.Ă‚Â Ă‚Â Based on these data, which genetic disease would yousuggest the patient is suffering from? (1 mark)
2.Ă‚Â Ă‚Â Name and describe the cellular process by which ofMLH1 is involved; and outcome of losing MLH1 gene expression .
3.  Name and describe the molecular basis of the processby which often involved in driving diminished expression of MLH1 . Describe also molecular mechanism a normal cell would useto counter act the “process” .
(C) Describe in details the advanced laboratory techniques bywhich you could use to study the “process” occurred to the MLH1locus.
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