Why doesn't having a gene variant associated with a particular illness or disorder guarantee a person will...

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Biology

Whydoesn't having a gene variant associated with a particular illnessor disorder guarantee a person will develop the condition?

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Genetic variation is defined as the variation in the DNA sequence in each of the genomes Both large and small changes in DNA sequences causes genetic variation and they cause some diseases But these variants always do not guarantee a person of developing the disease the level of penetrance and expressivity are responsible for the person developing that particular condition Example of this is breast cancer in this case people have a variation in a particular gene that is in BRCA1 gene have a higher tendency to develop cancer In this case cancer is the trait or condition But it is mentioned that it has a higher tendency leading towards cancer but do not guarantee because DNA variations which affects the BRCA1gene increase the risk of getting cancer but it do not guarantee it This is known as incomplete penetrance Genetic disorder is a genetic problem which occurs due to abnormalities in the genome it is a condition which is usually present since birth also called congenital Most genetic disorders are See Answer

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