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Why can some patients develop toxic responses to drugs even when their plasma levels are...

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Why can some patients develop toxic responses to drugs even when their plasma levels are in the therapeutic range?A. there is a higher level of the free fraction of the drug in the patient's plasmaB. there is a higher level of the bound fraction of the drug in the patient's plasmaC. drugs given before bed can become toxicD. A toxic response can not occur if the drug is within the therapeutic range

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