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Which one is the basis of a tumor achieving a malignant status as is evident...

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Biology

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Which one is the basis of a tumor achieving a malignant status as is evident in the progression of a benign colon polyp to malignant colon cancer A multiple mutations to proto oncogenes and or tumor suppressor genes B over expression of mitogen receptors OC heterozygosity of the tumor suppressor gene RB1 D activation of DNA replication during S phase O E genes of effectors down stream from Ras D and the RB1 gene

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