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Which ONE gives the commonly observed defect in cancer cells after both RB1 genes are...

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Biology

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Which ONE gives the commonly observed defect in cancer cells after both RB1 genes are mutated resulting in the genotype rb1 rbi O A PRB is no longer produced as a gene product cancer cells lack pRB OB transcription of RB1 gene is upregulated increasing the rate of production of pRB in cancer cells O C pRB mis folds causing its E2F binding site to exclude E2F OD the product of rb1 gene is capable of binding substantially more E2F than normal O E upstream regulators of pRB including Ras become constitutively activated

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