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Which of the following statements regarding voltage-gated sodium channels are TRUE? Choose all of the correct...

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Biology

Which of the following statements regarding voltage-gated sodiumchannels are TRUE? Choose all of the correct answers.

They actively transport sodium against its concentrationgradient.

They have two separate gating mechanisms: an activation gate andan inactivation gate.

They transition to the activated conformation upon membranedepolarization to above threshold potentials.

They directly participate in the mechanism forglucose-stimulated insulin secretion from pancreatic betacells.

Answer & Explanation Solved by verified expert
4.2 Ratings (549 Votes)
They have two separate gating mechanisms an activation gate and an inactivation gate Voltagegated sodium channels play an important role in action potentials If enough channels open when there is a change in the cells membrane potential a small but significant number of Na ions will move into the cell down their electrochemical gradient further depolarizing the cell Before an action potential occurs the axonal membrane is at its normal resting potential and Na channels are in their deactivated state blocked    See Answer
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