Which of the following statement(s) about p53 are true? p53 controls both the G2/M and the...

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Biology

Which of the following statement(s) about p53 are true?
p53 controls both the G2/M and the G1 cell cyclecheckpoints
The p53 tumor suppressor protein plays a key role in theregulation of the cell cycle and cell death
All of the above
p53 is tumor promoter protein
p53 involves in the Ub mediated proteolysis pathway
The p53 gene has a wide spectrum of mutations in humantumors
None of the above

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4.4 Ratings (566 Votes)

True p53 controls both the G2M and the G1 cell cycle checkpoints Increased expression of wildtype p53 in response to DNA damage arrests cells late in the G1 stage of the cell cycle by stimulating the synthesis of inhibitors of cyclindependent kinases such as p21WAF1 When p53 is expressed at a level comparable to that induced by DNA damage in other cells most MDAH041 cells arrested in G1 but a See Answer

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		p53 controls both the G2/M and the G1 cell cyclecheckpoints
		The p53 tumor suppressor protein plays a key role in theregulation of the cell cycle and cell death
		All of the above
		p53 is tumor promoter protein
		p53 involves in the Ub mediated proteolysis pathway
		The p53 gene has a wide spectrum of mutations in humantumors
		None of the above