Which of the following mechanisms are involved in mediating the increased prolactin secretion during lactation? [1.5...

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Biology

Which of the following mechanisms are involved in mediating theincreased prolactin secretion during lactation? [1.5 marks]
A . increased progesterone levels
B. increased sensitivity of prolactin negative feedback
C. decreased sensitivity of prolactin negative feedback
D. decreased prolactin gene expression due to the effects ofoestrogens during pregnancy
E. increased tyrosine hydroxylase activity and expression
please explain the answer.

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ANSWER OPTION CEXPLANATION Hormones in our body are tightly regulated and this regulationmainly happens by feedback regulationThis feedback regulationcan be of broadly 2 types1 Positive feedback regulation Sometimes the action of thehormone on a target tissue causes surplus secretion of hormone Eg secretion of luteinizing hormone LH action of estrogens on theanterior pituitary causes release of LH before ovulation Thissecreted LH further acts on the ovaries to secrete more estrogenswhich in turn stimulates the secretion of further LH from anteriorpituitary This action causes a triggered release of LH alsocalled as LH surge2 Negative feedback regulation The majority of the hormonessecreted by brain are regulated by the negative feedback mechanismWhen the See Answer

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