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When you mutate a Gly residue that immediately follows an alpha-helix to an Ala residue, the...

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Chemistry

When you mutate a Gly residue that immediately follows analpha-helix to an Ala residue, the protein becomes less stable of2.0 kcal/mol. Explain the molecular basis of this result.

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3.9 Ratings (532 Votes)
The energetics of alphahelix formation are fairly well understood and the helix content of a given amino acid sequence can be calculated with reasonable accuracy from helixcoil transition theories that assign to the different residues specific    See Answer
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