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When can a mutation in only one of the alleles for a locus in a diploid...

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Question

Biology

When can a mutation in only one of the alleles for a locus in adiploid cell have devastating effects for that cell ?

Group of answer choices

When the mutation affects a haploinsufficient locus

When it causes a synonymous mutation in the protein region of agene

When it completely abolishes the expression of the mutatedallele

When it causes a nonsense mutation downstream of the stop codonof a protein-coding gene

When it affects the coding sequence of a gene that is notnormally expressed in a that cell

Answer & Explanation Solved by verified expert
4.3 Ratings (638 Votes)
When the mutation affects a haploinsufficient locus Disorders caused by haploinsufficient genes usually have a dominant inheritance patternHaploinsufficiency may arise from a de novo or inherited lossoffunction    See Answer
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