What would be the metabolic effects of liver failure? Describe in detail. Discuss the pathways which...

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Biology

What would be the metabolic effects of liver failure? Describein detail. Discuss the pathways which will be affected and theeffects on other organs of the body. Remember the many functions ofthe liver. (15)
Identify the many functions and pathways in the liver which willnow be deficient. Both central metabolism and those of consequenceto other tissues (5 pts).

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Identify materials/chemicals used by other organs/tissues whichwould be deficient, effects on the pathways of these other tissuesand accumulation of toxins in the other tissues as a result of theliver biochemistry failure (5 pts).
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Overall effects on the other organs and tissues of the body (notthe liver). Explain what liver failure will do to the body, whattissues most affected and pathways most affected. Answer in lightof the big picture and reactions and pathways in othertissues/organs outside of the liver.Â Â

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1 Metabolic effects are liver failure Liver is the vital organ because it maintains homeostasis in the metabolism It performs this function by mainatining carbohydrate metabolism Fat metabolim aminoacid metabolism and also performs hormonal regulation In the case of liver failure the above processes described gets impaired leading to overal metabolic stress In the patients with cirrhosis liver cannot function in response to glucagon a hormone which maintains the blood glucose levels Moreover these patients have defects in the glycogen breakdown Glycogen is the source of glucose inthe periods of fasting If the glycogen cannot be utilised then the patients would be hypoglycemic state Lactate present in the foods are metabolised by liver In liver failure patients lactate concentration is high Glycerol concentration also remiains high in the blood in liver failure patients See Answer

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