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What is the basic constraint in recombination dictated by the 12/23 rule? Why does Vkjoin to Jkonly, and Vlto Jl...

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Biology

What is the basic constraint in recombination dictatedby the 12/23 rule? Why doesVkjoin toJkonly, andVltoJl only, and VH toDH to JH only?

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The adaptive immune response recognizes antigens through T and B lymphocytes antigen receptors These heterodimeric molecules have a variable antigenbinding domain with variable V diversity D only present in some loci and joining J gene segments Each gene is flanked by a canonical recombination signal sequence RSS RSS comprises conserved    See Answer
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