What is MALDI-TOF? How does it work? What can it tell us?

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Biology

What is MALDI-TOF? How does it work? What can it tell us?

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MALDI represents matrix assisted laser desorption ionisation and TOF represents timeofflight It is a mass spectrometry technique where charged fragments are produced and their mz mass to charge ratio is determined Here the ion is produced by MALDI and the TOF is the mass analyser Working of MALDITOF The basic principle of MALDI is to separate the individual analyte molecules from each other which is made possible by making their solid solution in a matrix material This matrix is composed of a particular material in large excess The choice of the matrix is variable Polar analytes go well with polar matrix while the non polar analytes with the non polar matrix Now the matrixanalyte solution is deposited onto a solid See Answer

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What is MALDI-TOF? How does it work? What can it tell us?

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What is MALDI-TOF? How does it work? What can it tell us?

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