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What happens with blockage of fast sodium channels? Am I correct to say that it increases...

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Medical Sciences

What happens with blockage of fast sodium channels? Am I correctto say that it increases refractory period as phase 0 of fast AP isdelayed? Does this mean a decrease in heart rate due to decrease inrate of contractility from decreased spread of depolarization?

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3.7 Ratings (500 Votes)

  • The blockade of fast sodium channels results in suppression/ depression of phse 0 depolarization whereby Vmax declines.
  • This results in prolongation of duration of action potential by decreasing conduction.
  • There is a decrease in the conductivity and increased refractoriness.
  • The cells are unable to undergo depolarization (due to blockade of sodium channels) and retard the generation of action potential.
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