What does the title phrase overcrowded milieu mean in the contextof in...

What does the title phrase â€˜overcrowded milieuâ€™ mean in the context of intrinsically disordered proteins, proteinaceous...

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Biology

What does the title phrase â€˜overcrowded milieuâ€™ mean in the contextof intrinsically disordered proteins, proteinaceous membrane-lessorganelles, and everything else constituting the cytoplasm? How doyou think IDPs and PMLOs fit into the overall cytoplasmic contentand at what ratio?

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Although the cellular interior is crowded with various biological macromolecules the distribution of these macromolecules is highly inhomogeneous Eukaryotic cells contain numerous proteinaceous membraneless organelles PMLOs which are condensed liquid droplets formed as a result of the reversible and highly controlled liquidliquid phase transitions The interior of these cellular bodies represents an overcrowded milieu since their protein concentrations are noticeably higher than those of the crowded cytoplasm and nucleoplasm PMLOs are different See Answer

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