What do you think would happen in mutant cells with the following defects and why? a....

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Biology

What do you think would happen in mutant cells with thefollowing defects and why? a. Cannot degrade M phase cyclins b.Inactivated CDK c. Have a mutated p53

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a Cannot degrade M phase cyclins M cdk cyclin complex is synthesized during S phase and G2 phase but it is activated only after the end of DNA replication The activated MCdk complex induces the chromosome condensation breakdown of nuclear membrane and mitotic spindle formation MCdk complex also activates the Anaphase Promoting Complex APC which in turn promotes the Anaphase changes in the cell division If M phase cyclins are not degraded the decondensation of chromosomes and reorganization of nuclear membrane does not occur the cells further undergo uncontrolled cell division which may lead to proliferation of the cell mass b Inactivated CDK Cyclin Dependent kinases Cdk complexes play a vital role in G1 check point G2 check point and M checkpoints G1 check point a critical checkpoint mediated G1Cdk complex allows the transition into of G1 phase to S phase and M Cdk complex act as G2 checkpoint after which the See Answer

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