What are the methods for calculating the free energy difference between two states? What are the...

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Physics

What are the methods for calculating the free energy differencebetween two states? What are the roles of MD/MC simulations forcalculating the free energy?
Name one of the enhanced sampling methods that utilize theMetropolis algorithm.

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1The methods for calculating the free energy difference between two states Free Energy Perturbation Thermodynamic Integration Slow Growth Method Umbrella Sampling and Histogram Methods Weighted    See Answer
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