Ubiquitination relies on 3 enzymes E1, which activate ubiquitin; E2, which are the conjugating enzymes, and...

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Ubiquitination relies on 3 enzymes E1, which activate ubiquitin;E2, which are the conjugating enzymes, and E3 enzymes, which helpguide the E2 enzymes to specific substrates. In any given cellthere are just a couple types of E1 enzymes, several types of E2enzymes that partner with small subsets of E3 enzymes, and evenmore types of E3 enzymes, which bind with small subsets of specificprotein substrates. Given this information, which of thesemutations would you hypothesize to be the mostharmful to a cell?\"
a.
a mutation in one type of E1 enzyme
b.
a mutation in one type of E2 enzyme
c.
a mutation in one type of E3 enzyme
d.
all of these mutations would be equally harmful

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Answer a Mutation in one type of E1 enzyme Explanation In the process of Ubiquitination a protein is inactivated by attaching Ubiquitin to it Ubiquitin is a small moleculeit acts like a tag which signals the protein transport mechanism It indicates to take the protein to the proteosome for degradation Proteosome are the protein complexes where degradation of unrequired and damaged proteins occur by the process of proteolysis it is a chemical reaction which breaks the peptide bonds See Answer

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	a.	a mutation in one type of E1 enzyme
	b.	a mutation in one type of E2 enzyme
	c.	a mutation in one type of E3 enzyme
	d.	all of these mutations would be equally harmful