Together with a specific set of proteins, snoRNAs direct the meth- ylation or pseudouridylation of rRNAs....

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Biology

Together with a specific set of proteins, snoRNAs direct themeth- ylation or pseudouridylation of rRNAs. Does the snoRNAfunction as a scaffold, guide, ribozyme, blocker, decoy, and/oralterer of protein function or stability?

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In this case Small nucleolar ribonucleoproteins snoRNPs are widely studied and characterized as guide RNAs for sequencespecific 2Oribose methylation and psuedouridylation of ribosomal RNAs In addition snoRNAs have also been shown to interact with some tRNAs and direct alternative splicing in mRNA biogenesis Recent advances in bioinformatics have resulted in new algorithms able to rapidly identify noncoding RNAs generally and snoRNAs specifically in genomic and metagenomic sequences resulting in a rapid increase in the number and diversity of identified snoRNA sequences The snoRNP database is a webbased collection of snoRNA and snoRNAassociated protein sequences from a wide range of species The database currently contains 8994 snoRNA sequences from Bacteria Archaea and Eukaryotes and 589 snoRNAassociated protein sequences The snoRNP database can be found at httpevolveathomecomsnoRNAsnoRNAphp Keywords sRNA sRNP small nucleolar RNA small nucleolar RNP INTRODUCTION The most wellknown function of small nucleolar ribonucleoprotein particles designated snoRNPs in Eukaryotes and sRNPs in Archaea is to catalyze the 2Oribose methylation CD snoRNPs and pseudouridinylation HACA snoRNPs of ribosomal RNAs The RNA components of snoRNP complexes are responsible for sequence specificity to the RNA target and possess no inherent catalytic or modification activity Direct base pairing between the snoRNA and the target RNA provides site specificity for the catalytic protein subunits associated with the guide snoRNA resulting in posttranscriptional modification of the target RNA Ribosomal RNAs are not the only target for snoRNPdirected nucleoside modification for example in Archaea some CD sRNPs as snoRNA See Answer

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