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To examine the hierarchy of signal sequence targeting in a cell, you construct a variety of...

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Biology

To examine the hierarchy of signal sequence targeting in a cell,you construct a variety of proteins containing differentcombinations of signal sequences. Based on your extensive knowledgeof protein targeting, predict the location of each of these fusionproteins listed below. Provide the logic for your predictions.

(A) ER signal sequence and NLS

(B) mitochondrial signal sequence and KDEL sequence

(C) matrix-targeting sequence and a stop-transfer sequence

Answer & Explanation Solved by verified expert
3.6 Ratings (511 Votes)
A Nuclear localization sequence NLS allows the protein to be transported to the nucleus NLS sequences are short sequences of about 6 to 8 amino acids with arginine and lysine amino acids basic or positive charged These sequences can associate with nuclear transport receptors TRs and helps in transport of cytosolic protein through nuclear membrane pores NLS sequences should be located with the protein as internal    See Answer
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