Think of a toy model of a dimeric receptor binding with a divalent ligand. The KDs...

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Biology

Think of a toy model of a dimeric receptor binding with adivalent ligand. The K_Ds for binding between a two-armedcompound LL1 (this is the ligand) and individualreceptors R1 and R2 are:
R1 â€¦ 7.9nMÂ Â Â Â Â Â Â Â Â Â Â Â R2 â€¦ 50.1 nM
Now think of a protein R1-R2, which is aprotein comprised of both R1 and R2. At a temperature 300K, ifthere is no loss of energy/entropy to induce conformational changesof the protein and ligand during the binding, what is the expectedK_D between LL1 and R1-R2 and corresponding deltaG?

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equilibria among monomeric proteins and a bivalent ligand equilibrium between a monovalent ligand l a monomeric protein p and a complicated of protein and ligand p l this equilibrium is characterised via the dissociation regular kd in which KdLPPL p See Answer

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