The sirtuins are a class of NAD-dependent deacetylases that are thought to play a role in...

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Biology

The sirtuins are a class of NAD-dependent deacetylases that arethought to play a role in the cellular response to nutritionalstatus. Some sirtuins are involved in remodeling chromatinstructure. A) How would you expect deacetylation of histones toaffect the transcriptional activity of genes? B) Sirtuin 3 (Sirt3)deacetylates a specific lysine in the active site of acetyl-CoAsynthetase, activating the enzyme. Why would this particulardeacetylation reflect nutritional status? Remember, acetyl-CoAsynthetase catalyzes the reaction: ATP + acetate + CoA <=>AMP + PPi + acetyl-CoA

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Ans The process of acetylation involves the relaxation of chromatin by removing positive charge from the histones which allows the fast and easy transcription of the genes On the contrary See Answer

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