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The molecular clock has limited usefulness for estimating divergence times among species in part due...

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The molecular clock has limited usefulness for estimating divergence times among species in part due to the saturation of DNA sequences This occurs because A DNA sequences are unable to revert back to previous allelic states B the variation in the substitution rate between closely related lineages prevents accurate estimation of divergence time C variation in population sizes among lineages changes the effect of genetic drift D in highly diverged lineages substitutions will occur at sites that have been substituted previously

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