The H2 antagonist burimamide showed poor bioavailability in clinical trials. (i) Define the term bioavailability. In your...

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Chemistry

The H2 antagonist burimamide showed poor bioavailability inclinical trials.
(i) Define the term bioavailability. In your answer, distinguishbioavailablility
from bioactivity.
(ii) Protonation of the imidazole ring was identified as a reasonfor the low
bioavailability of burimamide. Explain, using appropriatestructures, why
thiaburimamide, which features a sulfur atom in the alkyl chain,led to
increased bioavailability.
(iii) Thiaburimamide, also led to a modest increase inbioactivity. Propose a
reason for this increase in activity.

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3.6 Ratings (651 Votes)

I Bioavailability is fraction of administered drug that reaches the systemic circulation or bodys circulatory system It means it is rate at which drug is absorbed chemically See Answer

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