The genome of herpes-type viruses is linear double-stranded DNA. Acyclovir is an agent antiviral that inhibits...

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Biology

The genome of herpes-type viruses is linear double-stranded DNA. Acyclovir is an agentantiviral that inhibits DNA replication in cells infected by this virus. It is administered topatients in dephosphorylated form although it acts only after it is modified byphosphorylation.

a) Propose a possible mechanism of inhibition of replication.b) Acyclovir has very few side effects because it is only modified in cellsinfected. Explain.c) Herpes virus can become insensitive to acyclovir therapy by mutations in twogenes. Discuss what those genes might be.

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a Propose a possible mechanism of inhibition of replicationAcyclovir are nucleoside analogues that lacks free3 group In DNA replication new nucleosides are added to the3end of replicating chain Acyclovir triphosphate will bind withthe replicating viral gene and further nucleotide addition willcompletely prevents Also it See Answer

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