The concept of energy charge is a very useful way to think about how ATP levels...

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Chemistry

The concept of energy charge is a very useful way to think abouthow ATP levels control pathway activity. Discuss the role of ATP inthe glycolytic pathway (between glucose and pyruvate and/orlactate) with a focus on how energy charge would alter the pathwayand how the pathway activity would alter energy charge. Includeboth general aspects and specific ATP use and generation.

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Glycolysis was one of the first metabolic pathways studied andis one of the best understood in terms of theenzymes involved their mechanisms of action and the regulation ofthe pathway to meet the needs of theorganism and the cell The glycolytic pathway is extremely ancientin evolution and is common to essentially allliving organisms The earliest biochemical studies of glycolysisover 100 years ago used cell free extracts of yeastin which it was observed that glucose could be converted to carbondioxide and ethanol in the same manner carriedout by intact yeast cells to make beer and bread These experimentswere the first to demonstrate that thereactions of life were not inextricably tied to living cells butcould occur in a cellfreesystem the foundation ofmodern biochemistryIn glycolysis the See Answer

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