The clinical symptoms of two forms of galactosemia show radically different severity. Deficiency of galactokinase Deficiency of UDP-glucose:galactose...

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Biology

The clinical symptoms of two forms of galactosemia showradically different severity.
Deficiency of galactokinase
Deficiency of UDP-glucose:galactose 1-phosphateuridylyltransferase
Although both types produce gastric discomfort after milkingestion, deficiency of the transferase also leads to liver,kidney, spleen, and brain dysfunction and eventual death.
Explain, what products accumulate in the blood and tissues witheach type of enzyme deficiency? (3 point)
List the symptoms for each type of deficiency. (3 point).
Explain which of these products is more toxic and why?

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Answer A Galactosemia due to deficiency of enzyme galactokinase or Galk deficiency type 2 galactosemia Due deficiency of Galk enzyme Galactose is not phosphorylated into Galactose 1 Phosphate There is accumulation of Galactose in blood and tissues also the product of reaction Galactose 1 Phosphate becomes deficient See Answer

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