The cells accumulate neutral red (pKa=7), their lysosomes
swell-up to many times their normal size. The...
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Biology
The cells accumulate neutral red (pKa=7), their lysosomesswell-up to many times their normal size. The swelling cannot beaccounted for simply by the mass of accumulated neutral red. Canyou suggest what else may contribute to the swelling and why itoccurs?
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Lysosomes are subcellular organelles that contain hydrolytic enzymes required to degrade macromolecules in cell debris These enzymes are active in acidic pH that is maintained by the action of the vacuolar HATPase The pH within the lysosome is much lower
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