The activity of retinoblastoma protein (Rb) is regulated primarily by phosphorylation at various serine/threonine residues. Specific patterns...

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Biology

The activity of retinoblastoma protein (Rb) is regulatedprimarily by phosphorylation at various serine/threonine residues.Specific patterns of pRb phosphorylation generate pRbconformational variants that mediate distinct protein-proteininteractions. In an experimental cell system with a mutation in theRb gene that encodes alanine rather than serine, which isphosphorylated in the wild-type Rb, you observe that the cell isunable to enter into the cell cycle. What this observation suggestand how do you design an experiment to substantiate yoursuggestion?

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1 Retroblastoma gene is abdicated as Rb andits protein is abdicated as Rbp retinoblastoma proteingiven aspRb Note Retinoblastoma gene is a tumor suppressorand its function is to prevent excessive cell growth byinhibiting the cell cycle progression until cell is ready to divide Rb is able See Answer

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